卡培他滨-d11 是氘标记的卡培他滨。卡培他滨是一种口服前药，可通过胸苷磷酸化酶转化为其活性代谢物 5-FU。
货号:ajcx21992
CAS:1132662-08-8
分子式:C15H11D11FN3O6
分子量：370.4
溶解度:DMSO: Slightly Soluble,Methanol: Warmed
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Capecitabine-d₁₁is intended for use as an internal standard for the quantification of capecitabine by GC- or LC-MS. Capecitabine is a prodrug form of 5-fluorouracil .¹It is converted to 5-FUviaseveral enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC₅₀s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO 205, HCT116, and MCF-7 cells (IC₅₀s = >1,000 µM).

1.Miwa, M., Ura, M., Nishida, M., et al.Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissueEur. J. Cancer34(8)1274-1281(1998)