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BIBF 1120-13C-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIBF 1120-13C-d3图片
规格:98%
分子量:543.7
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21800
CAS:N/A
分子式:C30[13C]H30D3N5O4
分子量:543.7
溶解度:DMSO: 25 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

BIBF 1120-13C-d3is intended for use as an internal standard for the quantification of BIBF 1120 by GC- or LC-MS. BIBF 1120 is an inhibitor of the receptor tyrosine kinases VEGFR, FGFR, and PDGFR (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRα, and PDGFRβ, respectively).1It is selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM). BIBF 1120 inhibits growth factor-dependent proliferation of human umbilical vascular endothelial cells (HUVECs), human microvascular skin endothelial cells (HSMECs), human umbilical artery smooth muscle cells (HUASMCs), and bovine retinal pericytes (BRPs; EC50s = 7-290 nM).In vivo, BIBF 1120 (100 mg/kg) reduces tumor microvessel density and the number of PDGFRβ-expressing perivascular cells in a FaDu head and neck small cell carcinoma mouse xenograft model. It also inhibits tumor growth in a Caki-1 renal cancer mouse xenograft model. Formulations containing BIBF 1120 have been used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer (NSCLC).


1.Hilberg, F., Roth, G.J., Krssak, M., et al.BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacyCancer Res.68(12)4774-4782(2008)