| 规格: | 98% |
| 分子量: | 548.1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
Background:
Argatroban-d3is intended for use as an internal standard for the quantification of argatroban by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).1It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50value of 0.077 µM.2Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.
1.Park, H.D., Lee, S.H., Kim, T.H., et al.Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrugBioorganic & Medicinal Chemistry Letters23(17)4779-4784(2013) 2.Kato, Y., Kita, Y., Hirasawa-Taniyama, Y., et al.Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pigEur. J. Pharmacol.473(2-3)163-169(2003)
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