| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 2829元 |
| 分子量: | 544.5 |
Background:
Aranciamycin is a fungal metabolite that has been found inStreptomycesand has diverse biological activities.1,2It inhibitsC. histolyticumcollagenase but not elastase or trypsin in cell-free assays (IC50s = 0.37, >10, and >10 µM, respectively).1Aranciamycin is active againstM. bovisandB. subtilis(MICs = 30 and 15 µM, respectively).2It is cytotoxic to HepG2 cells (IC50= 18 µM).
1.Bols, M., Biderup, L., Hansen, J., et al.Inhibition of collagenase by aranciamycin and aranciamycin derivativesJ. Med. Chem.35(15)1768-2771(1992) 2.Khalil, Z.G., Raju, R., Piggott, A.M., et al.Aranciamycins I and J, antimycobacterial anthracyclines from an Australian marine-derived Streptomyces spJ. Nat. Prod.78(4)949-952(2015)
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