A neuropeptide with diverse biological activities
货号:ajcx21666
CAS:N/A
分子式:C194H295N53O58S.XCF3COOH
分子量：4329.8
溶解度:DMSO: 2 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Amyloid-β (1-40) (Aβ40) peptide is a 40-residue protein fragment of Aβ42 , a neurotoxic peptide found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.^1,2Aβ40 is more abundant, less neurotoxic, and does not form oligomers as easily as Aβ42.^3,4Aβ40 inhibitsin vitrofibrillization of Aβ42 in a concentration-dependent manner.⁵It also inhibits Aβ42-induced cell death in cultured rat embryonic cortical neurons in a concentration-dependent manner. Aβ40 prevents Aβ42-induced increases in the number of GFAP-positive astrocytes in rat entorhinal cortex.

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