SRI-011381 是一种口服活性 TGF-β 信号激动剂，具有神经保护作用。
货号:ajcx20114
CAS:1629138-41-5
分子式:C20H31N3O
分子量：329.5
溶解度:DMF: 15mg/mL,DMSO: 20mg/mL,Ethanol: 25mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SRI-011381 is an activator of TGF-β signaling.1 It reduces increases in cell death and the number of dystrophic neurites induced by amyloid-β (1-42) in primary mouse embryonic forebrain neurons when used at a concentration of 3 μM. SRI-011381 (2 and 5 μM) increases phagocytosis of Aβ42 by greater than 20% in J774A.1 and THP-1 macrophages. It increases contextual fear conditioning freezing time and spontaneous alternations in the Y-maze, indicating prevention of memory deficits, in the APP751Lon,Swe transgenic mouse model of Alzheimer's disease when administered at a dose of 10 mg/kg for 10 weeks.