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Prostaglandin F2αdiethyl amide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prostaglandin F2αdiethyl amide图片
规格:98%
分子量:409.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Prostaglandin F2α diethyl amide (PGF2α-NEt2) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide.
货号:ajcx18890
CAS:N/A
分子式:C24H43NO4
分子量:409.6
溶解度:DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 100 µ g/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Prostaglandin F2α diethyl amide (PGF2α-NEt2) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 µg/g corneal tissue/hr. However, we find that dialkyl amides such as PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity.