BRD7-IN-1是一种修饰的BI7273衍生物(BRD7/9抑制剂)，通过与VHL配体连接形成PROTACVZ185(VZ185抑制BRD7/9的DC50分别是4.5nM、1.8nM)。
货号:ajcx13584
CAS:2448414-48-8
分子式:C22H28Cl2N4O3
分子量：467.39
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1]. BRD7, BRD9[1]

[1]. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726.