GS-626510是一个有效的、且具有口服活性的BET家族的抑制剂，其对BRD2/3/4的Kd值为0.59-3.2nM，对BD1和BD2的IC50值分别为83nM和78nM。
货号:ajcx12904
CAS:1637770-13-8
分子式:C25H22N4O
分子量：394.47
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GS-626510 is a potent, and orally bioavailable BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively[1].

[1]. Sperandio D, et al. Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg Med Chem. 2019 Feb 1;27(3):457-469.