Propargyl-PEG3-acid是一种不可降解 (non-cleavable) 的含 3 个单元 PEG 的 ADC linker，同时也是基于PEG的PROTAC linker,可用于合成6-OHDA-PEG3-yne。6-OHDA-PEG3-yne 包含6-OHDA 和Propargyl-PEG3-acid。
货号:ajcx39670
CAS:1347760-82-0
分子式:C10H16O5
分子量：216.23
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377. [2]. Albone, Earl F, et al. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE. Patent. 20170252458.