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BLM-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BLM-IN-1图片
规格:98%
分子量:462.6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
BLM-IN-1 (compound 29) 是有效的、布鲁姆综合征蛋白 (BLM) 的抑制剂,对BLM的KD 值为1.81 μM,IC50 值为0.95 μM。可诱导DNA损伤反应,癌细胞的凋亡和增殖抑制。
货号:ajcx39562
CAS:2056014-40-3
分子式:C28H35FN4O
分子量:462.6
溶解度:DMSO : 8.33 mg/mL (18.01 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

BLM-IN-1 (compound 29) is an effective Bloom syndrome protein (BLM) inhibitor, with a strong BLM binding KD of 1.81 μM and an IC50 of 0.95 μM for BLM. Induces DNA damage response, as well as apoptosis and proliferation arrest in cancer cells[1].

[1]. Yin QK, et al. Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019 Mar 28;62(6):3147-3162.