包装: | 5mg |
规格: | 98% |
市场价: | 3969元 |
分子量: | 869.02 |
Background:
THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].
THAL-SNS-032 selectively induces degradation of CDK9[1].THAL-SNS-032 diminishes elongating polymerase II[1].THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].
[1]. Olson CM,et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170.