SDZ-MKS 492 (MKS 492) 一种选择性的环状 GMP 抑制的磷酸二酯酶 (III 型 PDE) 抑制剂。SDZ-MKS 492 抑制豚鼠和大鼠中抗原或血小板活化因子 (PAF) 诱导的支气管收缩和过敏反应。
货号:ajcx39314
CAS:114606-56-3
分子式:C20H27N5O6
分子量：433.46
溶解度:DMSO : 250 mg/mL (576.75 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats[1].

MKS 492 relaxes airway smooth muscle in vitro[2].

MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs[1].MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs[1].MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs[1].MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats[1].

[1]. Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13.
[2]. Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10.