AB-680 是一种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂，对 hCD73 的 Ki 值为 4.9 pM，对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性。
货号:ajcx39298
CAS:2105904-82-1
分子式:C20H24ClFN4O9P2
分子量：580.82
溶解度:DMSO : 200 mg/mL (344.34 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].

[1]. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.