CCI-006 是 MLL-重组白血病细胞的选择性抑制剂和化学增敏剂，通过抑制线粒体呼吸，导致 MLL-重组白血病细胞中不可克服的线粒体去极化和促凋亡的未折叠蛋白反应。
货号:ajcx39130
CAS:292053-42-0
分子式:C15H12N2O5S
分子量：332.33
溶解度:DMSO : ≥ 83.33 mg/mL (250.74 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1].

[1]. Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.