m-PEG7-CH2CH2COOH 是一种不可降解 (non-cleavable) 的 ADC linker，用于抗体偶联药物 (ADC) 的合成。m-PEG7-CH2CH2COOH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。
货号:ajcx39016
CAS:1093647-41-6
分子式:C18H36O10
分子量：412.47
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

m-PEG7-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG7-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Tinya Abrams, et al. Antibody drug conjugates. WO2016203432A1.

Protocol:

Non-cleavable

PEGs