VU0529331 是一种适度选择性的不含 GIRK1 的 G蛋白门控内向整流钾 (non-GIRK1/X) 通道抑制剂，在 HEK293 细胞中，对 GIRK2 和 GIRK1/2 的 EC50 值分别为 5.1 µM 和 5.2 µM，同时对 GIRK4 同源通道也有作用。
货号:ajcx38964
CAS:1286725-49-2
分子式:C22H20N6O
分子量：384.43
溶解度:DMSO : 5 mg/mL (13.01 mM; Need ultrasonic and warming)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1].

[1]. Kozek KA, et al. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. 2018 Sep 13.