SW-100 是一种有效的组蛋白脱乙酰基酶 6 (HDAC6) 抑制剂，IC50 值为 2.3 nM，相对于其他 HDAC 酶，对 HDAC6 的选择性至少高 1000倍。SW-100 显著提高了跨越血脑屏障的能力。
货号:ajcx38654
CAS:2126744-35-0
分子式:C17H17ClN2O2
分子量：316.78
溶解度:DMSO : ≥ 125 mg/mL (394.60 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].

SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner[1].

SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome[1].

[1]. Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.

Protocol:

HDAC1 5.23μM(IC50)

HDAC2 32.8μM(IC50)

HDAC3 29.5μM(IC50)

HDAC4 10.9μM(IC50)

HDAC5 4.07μM(IC50)

HDAC6 2.3nM(IC50)

HDAC7 4.55μM(IC50)

HDAC8 3.72μM(IC50)

HDAC9 3.46μM(IC50)

HDAC10 26.2μM(IC50)

HDAC11 5.72μM(IC50)