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Spirapril hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Spirapril hydrochloride图片
包装:5mg
规格:98%
市场价:2762元
分子量:503.07

产品介绍
Spirapril (SCH 33844) hydrochloride 是一种有效的血管紧张素转换酶 (ACE) 抑制剂,具有降压作用。Spirapril hydrochloride 竞争性地与 ACE 结合,阻止血管紧张素I向血管紧张素 II 的转化。Spirapril hydrochloride 是螺普利拉的一种口服活性前药,可用于高血压、充血性心力衰竭的研究。
货号:ajcx37924
CAS:94841-17-5
分子式:C22H31ClN2O5S2
分子量:503.07
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1].

Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2]

[1]. Spirapril. Drugbank.
[2]. B Maul, et al. Alcohol consumption is controlled by angiotensin II. FASEB J