SID7970631 作为一种异喹啉酮类似物，是一种有效的、选择性的亚微摩尔 SF-1 抑制剂 (IC50=260 nM)。SID7970631可用于癌症研究。
货号:ajcx37766
CAS:868224-75-3
分子式:C24H24N2O7
分子量：452.46
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2].

SID7970631 (CHO-K1 cells) displays a half-maximal cytotoxic effect. SID7970631 dose dependently inhibits luciferase expression in the SF-1 assay, giving the IC50 value of 255 nM. SID7970631 displays a cytotoxic effect not only on H295R/TR SF-1 cells, but also on SW-13 cells[1][2].

[1]. Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73(6):1776-1784.
[2]. Doghman M, et al. Identification and characterization of steroidogenic factor-1 inverse agonists. Methods Enzymol. 2010;485:3-23.