RNAENFDRF TFA 是 SAMβA 的肽。RNAENFDRF TFA 选择性拮抗 Mfn1-βIIPKC 结合。RNAENFDRF TFA 保护培养的新生儿和成人心肌细胞，但不保护 Mfn1 敲除细胞免受压力诱导的死亡。RNAENFDRF TFA 可重建心力衰竭大鼠的线粒体形态和功能并改善心肌收缩力。
货号:ajcx37738
CAS:N/A
分子式:C52H74F3N17O18
分子量：1282.24
溶解度:H2O : 50 mg/mL (38.99 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RNAENFDRF TFA is a peptide of SAMβA. RNAENFDRF TFA selectively antagonizes Mfn1-βIIPKC association. RNAENFDRF TFA protects cultured neonatal and adult cardiac myocytes, but not Mfn1 knockout cells, from stress-induced death. RNAENFDRF TFA re-establishes mitochondrial morphology and function and improves cardiac contractility in rats with heart failure[1].

[1]. Ferreira JCB, et al. A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun. 2019;10(1):329.