您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Cholesterol-13C2
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Cholesterol-13C2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cholesterol-13C2图片
规格:98%
分子量:388.64
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cholesterol-13C2 是 13C 标记的 Cholesterol。Cholesterol 是一种哺乳动物中的主要固醇,占质膜结构成分的 20-25%。 质膜对水具有高渗透性,但对离子和质子则相对不可渗透。Cholesterol 在确定膜的流动性和渗透性特征以及转运蛋白和信号蛋白的功能中起着重要作用。Cholesterol 还是一种内源性雌激素相关受体 α (ERRα) 激动剂。
货号:ajcx37692
CAS:78887-48-6
分子式:C2513C2H46O
分子量:388.64
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Cholesterol-13C2 is the 13C labeled Cholesterol. Cholesterol is the major sterol in mammals and is makes up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins[1][2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.