MRTX-EX185 是负载 GDP 的 KRAS 和 KRAS(G12D) 的有效抑制剂，对 KRAS(G12D) 的 IC50 值为 90 nM。MRTX-EX185 还结合 GDP 负载的 HRAS。
货号:ajcx37642
CAS:N/A
分子式:C33H33FN6O2
分子量：564.65
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS[1].

[1]. Vasta JD, et, al. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat Chem Biol. 2022 Mar 21.