您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CCT129957
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CCT129957
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CCT129957图片
规格:98%
分子量:309.32
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
CCT129957 是一种吲哚衍生物,也是一种有效的磷脂酶 C-γ (PLC-γ) 抑制剂,IC50 为 ~3 μM,GC50 为 15 μM。CCT129957 以约 15 μM 的浓度抑制鳞状细胞中 Ca2+ 的释放。
货号:ajcx37516
CAS:883098-58-6
分子式:C17H15N3O3
分子量:309.32
溶解度:DMSO : 100 mg/mL (323.29 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM[1][2].

The phenyl group on the left side sat in a lipophilic pocket formed of various amino acids. The predicted binding mode of CCT129957 displays a robust hydrogen bond pattern as well as a lipophilic contact[1].CCT129957 inhibits the cell growth of renal UO-31 and the breast T-47D cancer cell lines by ~60-70%[2].

[1]. Reynisson J, et al. The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem. 2009 Apr 15;17(8):3169-76.
[2]. Feng L, et al. The effect of PLC-γ2 inhibitors on the growth of human tumour cells. Eur J Med Chem. 2012 Aug;54:463-9.