Propargyl-PEG5-acid 是一种不可降解 (non-cleavable) 的含 5 个单元 PEG 的ADC linker，可用于合成抗体偶联药物 (ADC) 。Propargyl-PEG5-Boc 可用于合成 Galectin-3 的 ADC 抑制剂。Propargyl-PEG5-acid 是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。
货号:ajcx37062
CAS:1245823-51-1
分子式:C14H24O7
分子量：304.34
溶解度:DMSO : 100 mg/mL (328.58 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Zhang H, et al. Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjug Chem. 2018 Apr 18;29(4):1266-1275.