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Lenalidomide-C4-NH2 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lenalidomide-C4-NH2 hydrochloride图片
规格:98%
分子量:351.83
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
Lenalidomide-C4-NH2hydrochloride是一种基于Lenalidomide的,可募集CRBN蛋白的Cereblon配体。Lenalidomide-C4-NH2hydrochloride可通过linker与靶蛋白配体连接,形成PROTAC分子,如文献中的Compound24,其对RS4;11和MOLM-13细胞的IC50值分别为0.98nM和13.7nM。
货号:ajcx30906
CAS:N/A
分子式:C17H22ClN3O3
分子量:351.83
溶解度:DMSO: 130 mg/mL (369.50 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].


[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.