ABT-418hydrochloride是一种高效、选择性的nAChRs激动剂，具有增强认知和抗焦虑的作用。ABT-418hydrochloride激活胆碱能通道，可用于阿尔茨海默病的研究。
货号:ajcx30094
CAS:147388-83-8
分子式:C9H15ClN2O
分子量：202.68
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1].Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1].ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2].ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2]. Animal Model: Male SHRs (4-5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2]

[1]. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. [2]. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5.