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A2793
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A2793图片
规格:98%
分子量:265.69
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
A2793是有效的TWIK相关酸敏感K+通道1(TASK-1)的抑制剂,其IC50值为6.8μM。
货号:ajcx30086
CAS:88349-90-0
分子式:C13H12ClNO3
分子量:265.69
溶解度:DMSO: 100 mg/mL (376.38 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

A2793 is an efficient TWIK-related acid-sensitive K+ channel (TASK)-1 inhibitor, with an IC50 of 6.8 μM[1].

A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5)[1].A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1[1].


[1]. MiklÓs Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660.