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RF9 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RF9 hydrochloride图片
规格:98%
分子量:519.08
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
RF9 hydrochloride 是一种有效且有选择性的神经肽 FF 受体 (Neuropeptide FF receptor) 拮抗剂 ,对于 hNPFF1R 和 hNPFF2R 的 Ki 值分别为 58 和 7 nM。
货号:ajcx29654
CAS:N/A
分子式:C26H39ClN6O3
分子量:519.08
溶解度:DMSO: 50 mg/mL (96.32 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].

RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells[2].

RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[1].RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1]. Animal Model: Rats[1]

[1]. Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71. [2]. Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15;27(4):630-643.