NN-390 是一种有效的选择性 HDAC6 抑制剂，IC50 为 9.8 nM。 NN-390 穿透血脑屏障 (BBB)。 NN-390 在转移性 3 MB 组（髓母细胞瘤）中显示出研究潜力。
货号:ajcx28506
CAS:2490284-25-6
分子式:C17H16F4N2O4S
分子量：420.4
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NN-390 is an inhibitor of histone deacetylase 6 (HDAC6; IC₅₀= 9.8 nM).¹It is selective for HDAC6 over HDAC3, HDAC8, and HDAC11 (IC₅₀s = >1,000 nM for all). NN-390 is cytotoxic to MV4-11 leukemia, MM.1S multiple myeloma, and HD-MB03 medulloblastoma cells (IC₅₀s = 1.19, 1.38, and 0.13 µM, respectively).

1.Nawar, N., Bukhari, S., Adile, A.A., et al.Discovery of HDAC6-selective inhibitor NN-390 with in vitro efficacy in group 3 medulloblastomaJ. Med. Chem.65(4)3193-3217(2022)