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N-desmethyl Diltiazem(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-desmethyl Diltiazem(hydrochloride)图片
规格:98%
分子量:437
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An active metabolite of diltiazem
货号:ajcx28442
CAS:130606-60-9
分子式:C21H24N2O4S ? HCl
分子量:437
溶解度:Chloroform: soluble,DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

N-desmethyl Diltiazem is an active metabolite of the calcium channel inhibitor diltiazem.1It is formed from diltiazem by the cytochrome P450 (CYP) isoforms CYP3A4, CYP3A5, and CYP3A7.2N-desmethyl Diltiazem binds to isolated rat cerebral cortex homogenates (IC50= 323 nM) and inhibits spontaneous contractions in isolated rat portal veins (IC50= 489 nM).1It has been found as a contaminant in fresh water.3

1.Schoemaker, H., Hicks, P.E., and Langer, S.Z.Calcium channel receptor binding studies for diltiazem and its major metabolites: Functional correlation to inhibition of portal vein myogenic activityJ. Cardiovasc. Pharmacol.9(2)173-180(1987) 2.Williams, J.A., Ring, B.J., Cantrell, V.E., et al.Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7Drug Metab. Dispos.30(8)883-891(2002) 3.Marshall, M.M., and McCluney, K.E.Mixtures of co-occurring chemicals in freshwater systems across the continental USEnviron. Pollut.268(Pt. B)115793(2021)