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TCL053
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TCL053图片
规格:98%
分子量:874.3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
TCL053 是一种可离子化的脂质载体,用于将活性成分,特别是核酸,高效导入细胞。
货号:ajcx28296
CAS:2361162-70-9
分子式:C53H95NO8
分子量:874.3
溶解度:Ethanol: 25 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TCL053 is an ionizable amino lipid.1It has been used in the generation of lipid nanoparticles (LNPs) and has a pKavalue of 6.8. LNPs containing TCL053 and encapsulating mRNA encoding the Cas9 nuclease, in combination with LNPs containing TCL053 and encapsulating single-guide RNA (sgRNA) targeting the Rosa26 locus, have been used to induce CRISPR-mediated gene editing in the mouse gastrocnemius muscle.

1.Kenjo, E., Hozumi, H., Makita, Y., et al.Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in miceNat. Commun.12(1)7101(2021)