TCL053 是一种可离子化的脂质载体，用于将活性成分，特别是核酸，高效导入细胞。
货号:ajcx28296
CAS:2361162-70-9
分子式:C53H95NO8
分子量：874.3
溶解度:Ethanol: 25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TCL053 is an ionizable amino lipid.¹It has been used in the generation of lipid nanoparticles (LNPs) and has a pK_avalue of 6.8. LNPs containing TCL053 and encapsulating mRNA encoding the Cas9 nuclease, in combination with LNPs containing TCL053 and encapsulating single-guide RNA (sgRNA) targeting the Rosa26 locus, have been used to induce CRISPR-mediated gene editing in the mouse gastrocnemius muscle.

1.Kenjo, E., Hozumi, H., Makita, Y., et al.Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in miceNat. Commun.12(1)7101(2021)