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Mahanimbine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mahanimbine图片
规格:98%
分子量:331.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Mahanimbine 是一种来自咖喱叶的口服活性生物碱。
货号:ajcx22868
CAS:21104-28-9
分子式:C23H25NO
分子量:331.5
溶解度:DMSO: 10 mM
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Mahanimbine is a carbazole alkaloid that has been found inM. koenigiiand has diverse biological activities.1,2,3It is active againstS. aureusandS. pyogenes(MIC100= 50 µg/ml for both), as well asA. aegyptifourth instar larvae when used at a concentration of 100 µg/ml.1Mahanimbine induces cell cycle arrest at the G0/G1phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).2It decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity when administered orally at a dose of 30 mg/kg.3


1.Ramsewak, R.S., Nair, M.G., Strasburg, G.M., et al.Biologically active carbazole alkaloids from Murraya koenigiiJ. Agric. Food Chem.47(2)444-447(1999) 2.Pei, C., He, Q., Liang, S., et al.Mahanimbine exerts anticancer effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of AKT/mammalian target of rapamycin (mTOR) and signal transducer and activator of transcription 3 (STAT3) signalling pathwaysMed. Sci. Monit.246975-6983(2018) 3.Birari, R., Javia, V., and Bhutani, K.K.Antiobesity and lipid lowering effects of Murraya koenigii (L.) spreng leaves extracts and mahanimbine on high fat diet induced obese ratsFitoterapia81(8)1129-1133(2010)