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Doxazosin-d8(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doxazosin-d8(hydrochloride)图片
规格:98%
分子量:496
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An internal standard for the quantification of doxazosin
货号:ajcx22370
CAS:1219803-95-8
分子式:C23H17D8N5O5.HCl
分子量:496
溶解度:Acetonitrile:Methanol (1:1): soluble,DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Doxazosin-d8is intended for use as an internal standard for the quantification of doxazosin by GC- or LC-MS. Doxazosin is a non-selective antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.16, 1, and 3.98 nM for α1A-, α1B-, and α1D-ARs, respectively).1It inhibits norepinephrine-induced contractions in isolated rat aortic rings and human prostate strips with pA2values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2= 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.


1.Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al.Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studiesBr. J. Pharmacol.118(4)871-878(1996)