An internal standard for the quantification of AHU377
货号:ajcx21634
CAS:1884269-07-1
分子式:C24H25D4NO5
分子量：415.5
溶解度:Chloroform: Slightly Soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AHU377-d₄is intended for use as an internal standard for the quantification of AHU377 by GC- or LC-MS. AHU377 is a methyl ester prodrug form of the neprilysin inhibitor LBQ657 .¹It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.

1.Ksander, G.M., Ghai, R.D., deJesus, R., et al.Dicarboxylic acid dipeptide neutral endopeptidase inhibitorsJ. Med. Chem.38(10)1689-1700(1995)