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7β,27-dihydroxy Cholesterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7β,27-dihydroxy Cholesterol图片
规格:98%
分子量:418.7
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An oxysterol and agonist of RORγ and RORγt
货号:ajcx21530
CAS:240129-43-5
分子式:C27H46O3
分子量:418.7
溶解度:DMF: 2 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.30 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1]? It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 &#181M. It increases IL-17A production in Th17-polarized isolated human na?ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .

参考文献:
[1].Soroosh, P., Wu, J., Xue, X., et al.Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiationProc. Natl. Acad. Sci. USA111(33)12163-12168(2014)