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12-PAHSA-d31
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
12-PAHSA-d31图片
规格:98%
分子量:570.1
包装与价格:
包装价格(元)
100ug电议
250ug电议
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21086
CAS:N/A
分子式:C34H35D31O4
分子量:570.1
溶解度:DMF: 20 mg/ml,DMSO: 15 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

12-PAHSA-d31contains 31 deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5', 6, 6', 7, 7', 8, 8', 9, 9', 10, 10', 11, 11', 12, 12', 13, 13', 14, 14', 15, 15', 16, 16, and 16 positions. It is intended for use as an internal standard for the quantification of 12-PAHSA by GC- or LC-mass spectrometry. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity.1Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-PAHSA is a FAHFA in which palmitic acid is esterified on the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.112-PAHSA is present at 2- to 3-fold higher levels in adipose tissue of AG4OX mice compared to wild type mice.1Levels of 12-PAHSA are also higher in fasted wild-type mice compared to fed mice and are reduced upon high-fat diet-induced obesity in insulin-resistant mice.1


1.Yore, M.M., Syed, I., Moraes-Vieira, P.M., et al.Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effectsCell.159(2)318-332(2014)