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Ani 9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ani 9图片
规格:98%
分子量:332.8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Ani 9 是一种有效的选择性跨膜蛋白 16A (TMEM16A, Anoctamin-1) 阻断剂,IC50 为 77 nM。
货号:ajcx20520
CAS:356102-14-2
分子式:C17H17ClN2O3
分子量:332.8
溶解度:25mg/mL in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM).[1] It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.

参考文献:
[1]. Seo, Y., Lee, H.K., Park, J., et al. Ani9, A novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 11(5), e0155771 (2016).