iFSP1 是一种有效的、选择性的、不依赖谷胱甘肽的铁死亡抑制蛋白 1 (FSP1) (AIFM2) 抑制剂，EC50 为 103 nM。 iFSP1 在过表达 FSP1 的 GPX4 敲除细胞中选择性地诱导铁死亡。 iFSP1 能够使多种人类癌细胞系对铁死亡诱导剂敏感，例如 (1S,3R)-RSL3。
货号:ajcx20236
CAS:150651-39-1
分子式:C20H13N5
分子量：323.4
溶解度:1mg/mL in ethanol, 25mg/mL in DMSO, 30mg/mL in DMF
纯度：98%
存储：Store at -20°C
库存：现货

Background:

iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1).[1] It decreases cell viability in wild-type, but not glutathione peroxidase 4 (GPX4) knock-out, Pfa1 and HT1080 cells overexpressing AIFM2/FSP1, an effect that can be blocked by the ferroptosis inhibitor liproxstatin-1 . iFSP1 (3 μM) sensitizes a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3 .

参考文献:
[1].Doll, S., Freitas, F.P., Shah, R., et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature (2019).