您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CRT0066854
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CRT0066854
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CRT0066854图片
规格:98%
分子量:415.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
CRT0066854 是一种有效的选择性非典型 PKC 同工酶抑制剂。
货号:ajcx19360
CAS:1438881-19-6
分子式:C24H25N5S
分子量:415.6
溶解度:DMSO: 30 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CRT0066854 is an inhibitor of PKCΙ and PKCζ (IC50s = 132 and 639 nM, respectively).1 It also inhibits the Rho-associated kinase II (ROCK-II) kinase domain (IC50 = 620 nM). It is selective for these atypical PKCs and ROCK-II over typical PKCs and 98 other kinases in a panel at 1 μM. CRT0066854 decreases phosphorylation of the atypical PKC substrate lethal giant larvae 2 (LLGL2) in HEK293 cells expressing PKCΙ and LLGL2. It decreases viability of A549 lung carcinoma cells (IC50 = 3.47 μM) and decreases colony formation in HeLa cells by 65% when used at a concentration of 1 μM. CRT0066854 impairs lumen formation in MDCK cells in a Matrigel• assay and migration of NRK-49F cells in a wound assay.

参考文献
1. Kj•r, S., Linch, M., Purkiss, A., et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem. J. 451(2), 329-342 (2013).