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Doxorubicinol(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doxorubicinol(hydrochloride)图片
规格:98%
分子量:582
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Doxorubicinol is the major metabolite of doxorubicin, an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks.
货号:ajcx18412
CAS:N/A
分子式:C27H31NO11•HCl
分子量:582
溶解度:DMSO: Soluble,Methanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Doxorubicinol is the major metabolite of doxorubicin , an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. Doxorubicinol is formed by NADPH-dependent reduction of the side chain carbonyl group of doxorubicin in human, rabbit, and canine cardiac tissue. Doxorubicinol inhibits sodium-potassium-dependent ATPase activity (IC50 = 5.40 μg/ml) and ATP-dependent calcium uptake (IC50= 4.5 μg/ml) in canine cardiac muscle and increases resting stress in contracting rabbit cardiac muscle. Clinically observed cardiotoxicities following doxorubicin treatment have been attributed to the formation and cardiac action of doxorubicinol.