3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases.
货号:ajcx17882
CAS:N/A
分子式:C20H22N10O13P2•2Na
分子量：718.4
溶解度:Water: 10 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. It contains canonical 3'5'-phosphodiester bonds and regulates chemotaxis, colonization, and other cellular functions. 3'3'-cGAMP shows weaker binding to the adapter protein stimulator of interferon genes (STING; Kd = 1.04 µM) than 2'2'-cGAMP and 2'3'-cGAMP but has similar binding affinity to 3'2'-cGAMP (Kd = 1.61 µM) and cyclic di-GMP . 3'3'-cGAMP induces IFN-β mRNA expression in L929 cells (EC50 = 40.5 nM).