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17-chlorophenyl trinor Prostaglandin F2αethyl amide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17-chlorophenyl trinor Prostaglandin F2αethyl amide图片
规格:98%
分子量:450.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
货号:ajcx17810
CAS:N/A
分子式:C25H36ClNO4
分子量:450.1
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 0.1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. In addition, PGF2α can activate the PGE2 receptor EP1, albeit at higher concentrations, evoking inflammatory effects. Replacement of the ω-terminal three carbons with a phenyl group, producing 17-phenyl PGF2α, gives a ligand with both greater affinity for FP and diminished affinity for EP1. Compounds based on this structure are effective in lowering intraocular pressure, reducing ocular hypertension and limiting the progression of glaucoma. 17-phenyl PGF2α ethyl amide (Bimatoprost) is a prodrug which, after entering the cornea, is hydrolyzed to give the corresponding free acid. 17-chlorophenyl trinor Prostaglandin F2α ethyl amide has a chlorine atom substituted into the meta position of the phenyl group of 17-phenyl PGF2α ethyl amide. The meta substitution of a halogen (fluorine) at this site on the free acid increases its affinity for the FP receptor and greatly decreases its affinity for the EP1 receptor.