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Rotigaptide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rotigaptide图片
规格:98%
分子量:617.65
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Rotigaptide (ZP123) 是连接蛋白 43 (Cx43) 的特异性调节剂。Rotigaptide 可防止 Cx43 介导的间隙连接 (gap junction) 通讯的解偶联,并在急性代谢应激期间使细胞间通讯正常化。Rotigaptide 是一种抗心律失常肽 (AAP),有潜力用于心律失常-特别是房颤的相关研究。
货号:ajcx16622
CAS:355151-12-1
分子式:C28H39N7O9
分子量:617.65
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation[1][2].


[1]. Seyed Mojtaba Ghiasi, et al. The connexin 43 regulator Rotigaptide reduces cytokine-induced cell death in human islets [2]. Stahlhut M, et al. The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes.Cell Commun Adhes. 2006 Jan-Apr;13(1-2):21-7. [3]. KjØlbye AL, et al. Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.Basic Clin Pharmacol Toxicol. 2007 Oct;101(4):215-30.