SLX-4090，一种口服有效的、肠细胞特异性的微粒体甘油三酯转移蛋白 (MTP) 抑制剂，IC50 为 8.0 nM。SLX-4090 可用于血脂异常的研究。
货号:ajcx38104
CAS:913541-47-6
分子式:C31H25F3N2O4
分子量：546.54
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia[1].

SLX-4090 inhibits apolipoprotein B (IC50 value 9.6 nM) but not apolipoprotein A1 secretion in Caco-2 cells[1].

SLX-4090 (orally, 30 mg/kg) reduces postprandial lipids by 50% with an ED50 value 7 mg/kg in rats[1].

[1]. Enoch Kim, et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.