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Desmethyl cariprazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Desmethyl cariprazine图片
包装:5mg
规格:98%
市场价:4233元
分子量:413.38

产品介绍
Desmethyl cariprazine 是 Cariprazine 的活性代谢产物。Cariprazine,是抗精神病药候选药物,结合 D3, D2 和 5-HT1A 的 Ki 为 0.085 nM,0.49 nM,2.6 nM。
货号:ajcx34680
CAS:839712-15-1
分子式:C20H30Cl2N4O
分子量:413.38
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Desmethyl cariprazine is an active metabolite of Cariprazine[1]. Cariprazine, an antipsychotic drug candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM)[2].

[1]. Campbell RH, et al. Review of cariprazine in management of psychiatric illness. Ment Health Clin. 2018 Mar 23;7(5):221-229.
[2]. Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8.