N,N'-Dimethylthiourea(DMTU)是从黑蒜中分离出来的，是口服有效的羟基自由基(?OH)的清除剂，通过活化的中性粒细胞在体外阻止?OH的产生。N,N'-Dimethylthiourea通过发挥抗氧化作用，包括?OH清除和抗炎作用，防止水浸限制应激(WIRS)诱导的大鼠胃粘膜损伤。
货号:ajcx32170
CAS:534-13-4
分子式:C3H8N2S
分子量：104.17
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (?OH) and blocks ?OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including ?OH scavenging and anti-inflammatory action[1][2].

N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks[1].

[1]. Yoshiji Ohta, et al. Protective effect of N,N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats. Fundam Clin Pharmacol. 2017 Jun;31(3):319-328. [2]. Zhongyi Zhang, et al. Analysis of volatile compounds in fermented black garlic by GC-MS.