| 规格: | 98% |
| 分子量: | 333.43 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR)[1].
TP-TRFS (10 μM) exhibits weak fluorescence (φ = 0.57%, absolute quantum yield), and after TP-TRFS (10 μM)) is incubated with TCEP (1 mM), a dramatic fluorescence increment at 490 nm is observed (φ= 22.31%, absolute quantum yield) and the fluorescence intensity of the test system increased by B40-fold within 3 h[1].
TP-TRFS has the ability to visualize the TrxR activity in vivo, and also provides a mechanistic link between stroke and the loss of TrxR function, which may open up a new therapeutic window of stroke via the regulation of TrxR function[1].
[1]. Jintao Zhao, et al. Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. Chem Commun (Camb). 2020 Nov 12;56(90):14075-14078.
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