Fmoc-Ala-Glu-Asn-Lys-NH2是一种选择性天冬酰胺内肽酶AEP抑制肽，可抑制淀粉样前体蛋白APP裂解。AEP是一种pH值控制的半胱氨酸蛋白酶，在衰老过程中被激活并介导APP蛋白水解过程。
货号:ajcx31846
CAS:220701-06-4
分子式:C33H43N7O9
分子量：681.74
溶解度:DMSO: 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.