TRV120055是一种偏向Gq的激动剂，在AT1R-Gq融合蛋白上的分子效率是AT1R-βarr2融合蛋白的10倍。
货号:ajcx31620
CAS:2410957-04-7
分子式:C34H54N12O7
分子量：742.87
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TRV120055 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].

[1]. Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77. [2]. Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24.